SYNTHESIS AND CHARACTERIZATION OF SOME HETEROCYCLIC COMPOUNDS DERIVED FROM METOCLOPRAMIDE DRUG AND MEASUREMENT of BIOLOGICAL ACTIVITY

Abstract

This study included the synthesis of some new Schiff bases and heterocyclic compounds [1‐6] from the reaction of metoclopramide with some aromatic aldehydes by the classical Schiff method, then the Schiff bases were treated with chloroacetyl chloride and thioglycolic acid to obtain cyclic derivatives of beta-lactams [5,6] and 4-thiazolidinone [3,4], respectively. These derivatives were characterized by their melting points by FT IR, 1H NMR. Some compounds prepared were evaluated for their antioxidant activity by oxidation with 2,2-diphenyl-1-picrylhydryl (DPPH). Comparison of the antioxidant activity of the bioactive molecules of the compounds [3–6] with that of the conventional drug metoclopramide showed encouraging results.