DISPERSIVE LIQUID LIQUID MICRO EXTRACTION SPECTROPHOTOMETRIC DETERMINATION OF TELMESARTAN AND IRBESARTAN IN PHARMACEUTICALS SAMPLES

DISPERSIVE LIQUID LIQUID MICRO EXTRACTION SPECTROPHOTOMETRIC DETERMINATION OF TELMESARTAN AND IRBESARTAN IN PHARMACEUTICALS SAMPLES

  • قاسم مزبان صالح
  • محمد جاسم محمد حسن
  • سرمد بهجت ديكران
  • الباحث عباس طالب
Keywords: DLLME, microextraction, telmesartan, irbesartan, eriochrome black-T

Abstract

The current work is characterized by simplicity, accuracy and high sensitivity Dispersive liquid - Liquid Micro Extraction (DLLME). The method was developed to determine Telmesartan (TEL) and Irbesartan (IRB) in the standard and pharmaceutical composition. Telmesartan and Irbesartan are separated prior to treatment with Eriochrom black T as a reagent and formation ion pair reaction dye. The analytical results of DLLME method for linearity range (0.2- 6.0) mg /L for both drugs, molar absorptivity were (1.67 × 105-    5.6 × 105) L/ mole. cm, limit of detection were (0.0242and0.0238), Limit of quantification were (0.0821and0.0711), the Distribution coefficient were (238 and 226) and the preconcentration factor were (25) for Telmesartan (TEL) and Irbesartan (IRB) respectively. The assay has been used successfully in a determination study of both in pure and pharmaceutical preparations.

Author Biographies

قاسم مزبان صالح

1Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq [email protected]

محمد جاسم محمد حسن

2Assistant. Prof. Ph.D., Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq [email protected]

سرمد بهجت ديكران

3Prof. Ph.D. Department of Chemistry College of Education Ibn Al Haitham, Baghdad University, Iraq [email protected]

الباحث عباس طالب

4Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq [email protected]

Published
2020-12-31