SYNTHESIS, CHARACTERIZATION, AND STUDY THE BIOLOGICAL ACTIVITY OF SOME SCHIFF'S BASES, AND 1,3 - OXAZEPINE COMPOUNDS DERIVED FROM SULFAMETHOXAZOLE DRUG

SYNTHESIS, CHARACTERIZATION, AND STUDY THE BIOLOGICAL ACTIVITY OF SOME SCHIFF'S BASES, AND 1,3 - OXAZEPINE COMPOUNDS DERIVED FROM SULFAMETHOXAZOLE DRUG

  • Enaam F. Mousa
  • Ibtisam K. Jassim
Keywords: Keywords: Sulfamethoxazole , Schiff base , 1,3-Oxazepine, antibacterial activity .

Abstract

This study including synthesis of some new Schiff bases compounds [16] from the reaction of Sulfamethoxazole drug with some aromatic aldehydes in classical Schiff base method then treatment Schiff  bases with succinic anhydride to get oxazepines rings [7-11]These derivatives were characterized by melting point, FTIR, 1H NMR and mass spectra. Some of synthesized compounds were evaluated in vitro for their antibacterial activities against three kinds of pathogenic strains Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by agar diffusion disk method, and against the fungal species (Candida). The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.

Author Biographies

Enaam F. Mousa

1Lecturer MSc. Department of Chemistry, College of Sciences for women, University of Baghdad, Baghdad, Iraq. [email protected]

Ibtisam K. Jassim

2Professor PhD., Department of Chemistry, College of Education-Ibn-Al-Haitham, University of Baghdad, Baghdad, Iraq. [email protected]

Published
2021-06-30
How to Cite
Mousa, E., & Jassim, I. (2021). SYNTHESIS, CHARACTERIZATION, AND STUDY THE BIOLOGICAL ACTIVITY OF SOME SCHIFF’S BASES, AND 1,3 - OXAZEPINE COMPOUNDS DERIVED FROM SULFAMETHOXAZOLE DRUG. Iraqi Journal of Market Research and Consumer Protection, 13(1), 43-54. Retrieved from https://jmracpc.uobaghdad.edu.iq/index.php/IJMRCP/article/view/228