SPECTROPHTOTOMETRIC DETERMINATION OF PURE SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS BY OXIDATIVE COUPLING REACTION

SPECTROPHTOTOMETRIC DETERMINATION OF PURE SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS BY OXIDATIVE COUPLING REACTION

  • Noor M. Ghaib Allah
  • Abdul M. K. Ahmed
  • Nashwan O. Tapabashi
Keywords: Spectrophotometric, pharmaceutical, sulfamethoxazole, oxidative coupling.

Abstract

            A new, simple, rapid and sensitive spectrophotometric method for the determination of sulfamethoxazole in both pure form and pharmaceutical preparations has been reported.The adapted technique based on utilization 4-aminobenzene sulfonic acid as a new modern chromogenic through an oxidative coupling reaction with sulfamethoxazole and potassium iodate in basic media to form orange soluble dye product with absorption maxima at 490 nm. Subject to Beer's law in the range 2–32μg mL-1. The values of molarabsorption coefficient (ε) and correlation coefficient were found to be 9.118 × 103 and0.9999 respectively whereas the Sandels index was 0. 02778 µg.cm-2.

Author Biographies

Noor M. Ghaib Allah
Abdul M. K. Ahmed

2Chemistry Department, Faculty of Education for Pure Sciences, Kirkuk University, Kirkuk, Iraq. [email protected]

Nashwan O. Tapabashi

3College of Pharmacy, Kirkuk University, Kirkuk, Iraq. [email protected]

Published
2021-06-30
How to Cite
Ghaib Allah, N., Ahmed, A., & Tapabashi, N. (2021). SPECTROPHTOTOMETRIC DETERMINATION OF PURE SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS BY OXIDATIVE COUPLING REACTION. Iraqi Journal of Market Research and Consumer Protection, 13(1), 65-76. Retrieved from https://jmracpc.uobaghdad.edu.iq/index.php/IJMRCP/article/view/230