SYNTHESIS OF NEW LEVOFLOXACIN SELECTIVE MEMBRANE SENSOR BASED ON MOLECULARLY IMPRINTED POLYMERS.

SYNTHESIS OF NEW LEVOFLOXACIN SELECTIVE MEMBRANE SENSOR BASED ON MOLECULARLY IMPRINTED POLYMERS.

  • Saja F. Abdullah
  • Yehya K. Al-Bayati
Keywords: Molecularly impressed electrodes, levofloxacin, potentiometric method, styrene (STY) monomer.

Abstract

Two molecular imprinted polymer (MIP) membranes for Levofloxacin (LEV) were prepared based on PVC matrix. The imprinted polymers were prepared by polymerization of styrene (STY) as monomer, N,N methylene di acrylamide as a cross linker ,benzoyl peroxide (BPO) as an initiator and levofloxacin as a template. Di methyl adepate (DMA) and acetophenone (AOPH) were used as plasticizers , the molecular imprinted membranes and the non molecular imprinted membranes were prepared.  The slopes and detection limits of the liquid electrodes ranged from -21.96 – -19.38 mV/decade and 2×10-4M- 4×10-4M, and Its response time was around 1 minute, respectively. The liquid  electrodes were packed with 0.1 M standard drug solution and its response were stable at pH ranges from 1.0 to 11.0 and with good selectivity for more than several type. The electrodes produced have been successfully applied in preparation of the pharmaceutical sample for the determination of the analyte without any time consuming pretreatment steps.

Author Biographies

Saja F. Abdullah

1Chemical Assistant, Department of Chemistry, College of Sciences, University of Baghdad, Baghdad, Iraq. [email protected]

Yehya K. Al-Bayati

2Professor PhD., Chemistry Department, College of Science, University of Baghdad, Iraq. [email protected]

Published
2021-06-30
How to Cite
Abdullah, S., & Al-Bayati, Y. (2021). SYNTHESIS OF NEW LEVOFLOXACIN SELECTIVE MEMBRANE SENSOR BASED ON MOLECULARLY IMPRINTED POLYMERS. Iraqi Journal of Market Research and Consumer Protection, 13(1), 95-107. Retrieved from https://jmracpc.uobaghdad.edu.iq/index.php/IJMRCP/article/view/233