STUDY OF THE EFFECT OF CHITOSAN EXTRACTED FROM THE MUSHROOM ON THE EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN MALE RABBITS

STUDY OF THE EFFECT OF CHITOSAN EXTRACTED FROM THE MUSHROOM ON THE EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN MALE RABBITS

Authors

  • Ibrahim K. H. Aldulimy1
  • Asmaa H. Shaker2
  • Fahad K. Y Al-dulaimi3

Keywords:

Keywords: Chitosan, Mushroom, Hyperlipidemia.

Abstract

The present study aimed to identify the therapeutic evaluation of chitosan extracted from the fungus cushroom and pure chitosan on glucose and lipid profile in the blood of 35 male rabbits with hyperlipidemia induced experimentally by cholesterol. The tests included estimation of glucose levels, total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, and very low-density lipoproteins. hyperlipidemia was induced in the male rabbits used in the study which was administered orally with cholesterol 150mg/kg body weight for a week. rabbits were divided into seven groups: control, cholesterol, pure chitosan, mushroom chitosan, cholesterol and pure chitosan, cholesterol and mushroom chitosan and cholesterol and simvastatin. The results of the study showed, the hyperlipidemia induced experimentally resulted a significant increase (P<0.05) in TC, TG, LDL, and VLDL, while no significant difference in HDL compared with control group, on the otherwise the glucose level significantly increase than control. Also, groups of animals treatment with pure chitosan and mushroom chitosan showed a significant decrease (P<0.05) in glucose, TC, TG, LDL, and VLDL, and no significant difference in HDL compared with control group. While, the groups showed treatment with cholesterol and pure chitosan, cholesterol and mushroom chitosan, cholesterol and simvastatin a significant decrease (P<0.05) in glucose, TC, TG, LDL, and VLDL, and a significant increase (P<0.05) in HDL compared with the cholesterol group. The research study revealed that chitosan extracted from mushroom can control the levels of fat concentrations and their complications, in addition to its important role in biochemical variables, and treatment of most disease cases, especially cardiovascular disease.

Author Biographies

Ibrahim K. H. Aldulimy1

1Researcher, Department of Chemistry, College of Education for Women, University of Tikrit, Salah al-Din, Iraq. [email protected]

Asmaa H. Shaker2

2Assistant. Professor PhD., Department of Chemistry, College of Education for Women, University of Tikrit, Salah al-Din, Iraq. [email protected]

Fahad K. Y Al-dulaimi3

3Assistant. Professor PhD., Northern Technical University, Salah al-Din, Iraq. [email protected]

Published

2021-12-31

How to Cite

Aldulimy1, I. K. H., Shaker2, A. H., & Y Al-dulaimi3, F. K. (2021). STUDY OF THE EFFECT OF CHITOSAN EXTRACTED FROM THE MUSHROOM ON THE EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN MALE RABBITS: STUDY OF THE EFFECT OF CHITOSAN EXTRACTED FROM THE MUSHROOM ON THE EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN MALE RABBITS. Iraqi Journal of Market Research and Consumer Protection, 13(2), 79–88. Retrieved from https://jmracpc.uobaghdad.edu.iq/index.php/IJMRCP/article/view/249