SYNTHESIS AND CHARACTERIZATION OF NEW HETEROCYCLIC DERIVATIVES FROM 7- HYDROXY -4- METHYL COUMARIN AND STUDY ANTIOXIDANT ACTIVITY FOR SOME SYNTHETIC COMPOUNDS

Abstract

      7-Hydroxy-4-methyl coumarin(H₁) compound have been synthesized by resorcinol and ethyl acetoacetate reaction. 4-methyl-2-oxo-2H-chromen-7-yl 2-chloroacetate(H₂) is highly reactive compounds. It has been used as intermediate in some reactions. It has been synthesized and reacted with hydrazine hydrate to produce4-methyl-2-oxo-2H-chromen-7-yl 2-hydrazinylacetate (H₃).Schiff Bases Compound (H₄) is synthesized by reacting the compound (H₃) with P-hydroxy benzaldehyde, then reacted(H₄) with sodium azide, mercaptoacetic acid, chloroacetyl chloride and anhydrides such as (3- nitro phathalic anhydride, maleic anhydride, succinic anhydride) which produced tetrazole(H₅), thiazolidinone (H₆), β–Lactam (H₇), and Oxazepine Compounds(H₈-H₁₀) respectively. The prepared derivatives have been identified by FT-IR, ¹HNMR. Some of these compounds have bene screened for their antioxidant activity.