ATHEROGENIC INDICATIONS IN THYROIDISIM PATIENTES AND THE RISK OF CARDIOVASCULAR DISEASES

Abstract

The body's energy metabolism can be significantly affected by thyroid diseases, making them a prime concern for medical professionals. Despite this, traditional lipid profile tests are still commonly used by physicians to diagnose these conditions. The aim of the current study is to assess the efficacy of several atherogenic indices in predicting the risk of cardiovascular disease among patients with thyroid dysfunction, including the atherogenic index of plasma (AIP), Castelli's risk index I and II (CRI-I and II), the atherogenic coefficient (AC), and the cholesterol index (CHOL index).Methods: A100 woman was involved in this study which  diagnosed with thyroid dysfunction, and their thyroid hormone levels were used to divide them equally into two groups: Hyperthyroidism patients (n=50) with aged 18-60 years old and Hypothyroidism with patients (n=50) with aged 18-75 years old. Additionally, 30 healthy women between the ages of 18 and 70 were included as a control group. To collect data, demographic and clinical measurements were taken, including body mass index (BMI), age, weight, lipid profile and  atherogenic indices such as AIP, CRI-I, CRI-II, AC, and CHOL index. Thyroid hormone levels (TSH, T₃ and T₄, freeT₃, freeT₄) were also recorded for all participants. Results: The calculated atherogenic indices of the patients and controls revealed the presence of significant increase (P<0.05) in these indices in both thyroidism patients groups when compared with that of control group. Conclusions: These results suggest that patients with thyroidism are at high risk to cardiovascular diseases and the regular monitor for dyslipidemia is very important in order to start an early treatment and advise them for changing their life style.