PREPARATION AND ANALYSIS OF MOLECULARLY IMPRINTED SOLID-PHASE EXTRACTION FOR DIAZEPAM AND ITS PHARMACEUTICAL APPLICATIONS BASED ON ACID MONOMERS USING A BULK POLYMERIZATION METHOD

Abstract

A molecularly imprinted polymer was used to make two electrodes (MIP). MIP was manufactured using Diazepam (DZP) as the template, 2-acrylamido-2-methyl-1-propan sulfanic acid as the monomer, and N.N-methylene bis acrylamide as the cross-linker. Non-imprinting polymers (NIP) were created using the identical composition, minus the template (Diazepam). Tritolyl phosphate (TTP) and dibutyl sebacate (DBS) are examples of plasticisers utilised in the PVC matrix to produce films. DZP-MIP electrode slope, detection limit, durability, and linearity range are evaluated. The outcomes of the selectivity measurements on the interfering cations (Al ^{+ 3}, Ca ^{+ 2}, and K ⁺¹) indicate that they do not inhibit Diazepam. The produced electrode exhibited   favorable response, including to conduct research on pharmaceuticals.